| Modulating or suppressing effects of antibiotics on the aquatic immune system |
| Paper ID : 1012-ICIAQUA |
| Authors |
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Majid Khanzadeh *1, Seyed Hossein Hoseinifar2 1Animal Biological Product Research Group, Academic Center for Education, Culture and Research (ACECR), Tehran,Tehran Organization, Iran 2Faculty of Fisheries and Environmental Sciences, Gorgan University of Agricultural Sciences and Natural Resources, Gorgan, Iran |
| Abstract |
| Immune system needs time and energy to deal with pathogens and expenditure of energy and time causes delay in reproduction and the disease progresses.Therefore, compounds such as antibiotics can help the immune system in the process of fighting and defending. Antibiotics weaken the bacteria and deactivate them, and the immune system does the final cleaning.Some antibiotics exacerbate inflammatory reactions and cause tissue damage in severe infections, while others reduce inflammatory reactions.These properties of intensifying inflammation and reducing inflammation are very important when choosing antibiotics to treat diseases.The mechanism of stimulation and increase of inflammatory responses of antibiotics is related to a group of antibiotics that target the cell wall of bacteria. These antibiotics destroy the bacterial cell wall and cause the release of inflammatory compounds from the bacteria, after which the immune system starts an inflammatory reaction.While antibiotics that prevent inflammatory responses focus more on inhibiting the synthesis of bacterial proteins, such as the group of Macrolides that inhibit protein synthesis in Gram-positive and negative bacteria and stop the production of virulence factors such as biofilm and toxins. Also, another group of antibiotics such as Fluoroquinolones, Imidazole and Tetracycline directly affect immune cells and prevent the production of inflammatory mediators. Some other antibiotics, such as Ciprofloxacin, in addition to affecting bacteria, change the metabolism of normal body cells, especially immune cells. In general, although antibiotics help the immune system of living organisms to eliminate bacteria, they can act as a double-edged sword to modulate the immune system and develop diseases. |
| Keywords |
| Antibiotic, Immune system, Pathogen, Aquaculture |
| Status: Abstract Accepted (Poster Presentation) |